Here, guests would rest and eat, change horses and have them drink from the cool fountain in front of the villa, which still today vaunts the Grand Ducal coat of arms flanked by two statues representing Justice and Abundance. The massive building's façade features a double loggia with six arches, one at street level and the other on the upper floor.
The villa also hosted a number of illustrious guests, including Pope Pius VI and Pius VII, Grand Duke Ferdinand I, Cosimo II, Leopold II, writer Thomas Gray, the Marquis De Sade, Stendhal, François René de Chateaubriand and Charles Dickens, who after staying here in 1863 remaked, "It was a bad morning when we left this place; and we went, for twelve miles, over a country as barren, as stony, and as wild, as Cornwall in England, until we came to Radicofani, where there is a ghostly, goblin inn: once a hunting-seat, belonging to the Dukes of Tuscany. It is full of such rambling corridors, and gaunt rooms, that all the murdering and phantom tales that ever were written might have originated in that one house."
The Posta Medicea of Radicofani is privately owned and is currently not open to the public.